Both the Mustang Mach-E and Tucson Plug-In Hybrid have child safety locks to prevent children from opening the rear doors. The Mustang Mach-E has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Tucson Plug-In Hybrid’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The Ford Mustang Mach-E has a standard driver’s side knee airbag mounted low on the dashboard. The knee airbag helps prevent the driver from sliding under the seatbelts or the main frontal airbag; this keeps the driver better positioned during a collision for maximum protection. A knee airbag also helps keep the legs from striking the dashboard, preventing knee and leg injuries in the case of a serious frontal collision. The Tucson Plug-In Hybrid doesn’t offer knee airbags.
The Mustang Mach-E has standard Post Collision Braking, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Tucson Plug-In Hybrid doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the Mustang Mach-E and the Tucson Plug-In Hybrid have standard driver and passenger frontal airbags, front and rear side-impact airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Ford Mustang Mach-E is safer than the Tucson Plug-In Hybrid:
| 
 | Mustang Mach-E | Tucson Plug-In Hybrid | 
| Overall Evaluation | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 115 | 121 | 
| Torso | ACCEPTABLE | ACCEPTABLE | 
| Pelvis | GOOD | GOOD | 
| Head Protection | GOOD | GOOD | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Injury Criterion | 42 | 116 | 
| Torso | GOOD | ACCEPTABLE | 
| Shoulder Deflection | .87 in | 1.1 in | 
| Torso Max Deflection | .94 in | 1.38 in | 
| Torso Deflection Rate | 4 MPH | 5 MPH | 
| Pelvis | GOOD | GOOD | 
| Pelvis Force | 535 lbs. | 669 lbs. | 
| Head Protection | GOOD | GOOD | 

