With its standard Pre-Collision Assist with Automatic Emergency Braking, the Ford Mustang Mach-E is better at preventing collisions with pedestrians than the Genesis Electrified G80, according to the Insurance Institute for Highway Safety:
| 
 | Mustang Mach-E | Electrified G80 | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | AVOIDED | 
| 25 MPH | AVOIDED | AVOIDED | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | -11 MPH | 
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | -22 MPH | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| 37 MPH Brights | -33 MPH | -20 MPH | 
| Warning Issued-Brights | 1.6 sec | 1.1 sec | 
The Mustang Mach-E has standard Post Collision Braking, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Electrified G80 doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the Mustang Mach-E and the Electrified G80 have standard driver and passenger frontal airbags, front and rear side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and driver alert monitors.
Side impacts caused 23% of all road fatalities in 2018, down from 29% in 2003, when the Insurance Institute for Highway Safety introduced its side barrier test. In order to continue improving vehicle safety, the IIHS has started using a more severe side impact test: 37 MPH (up from 31 MPH), with a 4180-pound barrier (up from 3300 pounds). The results of this newly developed test demonstrates that the Ford Mustang Mach-E is safer than the Electrified G80:
| 
 | Mustang Mach-E | Electrified G80 | 
| Overall Evaluation | GOOD | GOOD | 
| 
 | Driver Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Head Peak Forces | no contact | 35 G’s | 
| Torso Deflection Rate | 9 MPH | 12 MPH | 
| Pelvis | GOOD | GOOD | 
| Head Protection | GOOD | ACCEPTABLE | 
| 
 | Passenger Injury Measures | |
| Head/Neck | GOOD | GOOD | 
| Torso | GOOD | GOOD | 
| Pelvis | GOOD | GOOD | 
| Pelvis Force | 535 lbs. | 669 lbs. | 
| Head Protection | GOOD | ACCEPTABLE | 

