In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the Mustang Mach-E are reminded to check the back seat if they opened the rear door before starting out. The Q8 e-tron doesn’t offer a back seat reminder.
With its standard Pre-Collision Assist with Automatic Emergency Braking, the Ford Mustang Mach-E is better at preventing collisions with pedestrians than the Audi Q8 e-tron, according to the Insurance Institute for Highway Safety:
| 
 | Mustang Mach-E | Q8 e-tron | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | -10 MPH | 
| 25 MPH | AVOIDED | AVOIDED | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | AVOIDED | 
| 25 MPH Brights | AVOIDED | -23 MPH | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
Over 200 people are killed each year when backed over by motor vehicles. The Mustang Mach-E has a standard Reverse Brake Assist that uses rear sensors to monitor for objects to the rear and automatically applies the brakes to prevent a collision. The Q8 e-tron doesn’t offer automatic braking for stationary objects directly to the rear.
The Mustang Mach-E’s driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Q8 e-tron doesn’t offer a driver alert monitor.
Both the Mustang Mach-E and the Q8 e-tron have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, post-collision automatic braking systems, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras and rear cross-path warning.

