The F-150 has standard Post-Collision Braking, which automatically apply the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Titan doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the F-150 and Titan have rear cross-traffic warning, but the F-150 has Cross Traffic Braking (automatically applies the brakes) to better prevent a collision when backing near traffic. The Titan’s Rear Cross Traffic Alert doesn’t automatically brake.
Both the F-150 and the Titan have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front seatbelt pretensioners, height adjustable front shoulder belts, plastic fuel tanks, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors, available four-wheel drive and around view monitors.
The National Highway Traffic Safety Administration does 35 MPH front crash tests on new vehicles. In this test, results indicate that the Ford F-150 is safer than the Nissan Titan:
| 
 | F-150 | Titan | 
| OVERALL STARS | 5 Stars | 4 Stars | 
| 
 | Driver | |
| STARS | 4 Stars | 4 Stars | 
| Neck Injury Risk | 30% | 31% | 
| Neck Stress | 300 lbs. | 364 lbs. | 
| Neck Compression | 27 lbs. | 84 lbs. | 
| Leg Forces (l/r) | 25/46 lbs. | 123/436 lbs. | 
| 
 | Passenger | |
| STARS | 5 Stars | 3 Stars | 
| Chest Compression | .4 inches | .4 inches | 
| Neck Injury Risk | 28% | 70% | 
| Neck Stress | 152 lbs. | 263 lbs. | 
| Neck Compression | 65 lbs. | 80 lbs. | 
| Leg Forces (l/r) | 104/35 lbs. | 331/276 lbs. | 
New test not comparable to pre-2011 test results. More stars = Better. Lower test results = Better.
The National Highway Traffic Safety Administration does side impact tests on new vehicles. In this test, which crashes the vehicle into a flat barrier at 38.5 MPH and into a post at 20 MPH, results indicate that the Ford F-150 is safer than the Nissan Titan:
| 
 | F-150 | Titan | 
| 
 | Front Seat | |
| STARS | 5 Stars | 5 Stars | 
| HIC | 31 | 40 | 
| Hip Force | 142 lbs. | 225 lbs. | 
| 
 | Into Pole | |
| STARS | 5 Stars | 5 Stars | 
| Max Damage Depth | 13 inches | 17 inches | 
| Hip Force | 432 lbs. | 845 lbs. | 
New test not comparable to pre-2011 test results. More stars = Better. Lower test results = Better.
Instrumented handling tests conducted by the National Highway Traffic Safety Administration and analysis of its dimensions indicate that the F-150 is .7% to 6.4% less likely to roll over than the Titan.
For its top level performance in IIHS driver and passenger-side small overlap frontal, moderate overlap frontal, side impact, roof strength and head restraint tests, its standard vehicle-to-vehicle front crash prevention system, its standard vehicle-to-pedestrian front crash prevention system, and its available headlight’s “Good” rating, the Insurance Institute for Highway Safety grants the F-150 the rating of “Top Safety Pick” for 2022, a rating granted to only 163 vehicles tested by the IIHS. The Titan last would have qualified as a “Top Safety Pick” in 2017.

